Service

Information for

About JCCM

Links

www.ebscohost.com www.embase.com www.cabi.org www.doaj.org www.ncbi.nlm.nih.gov www.csa.com www.cas.org www.indexcopernicus.com www.chceo.net www.yaoshi.org.cn

N/A

Content in briefVOL.5.NO.2.2010

Immune response in histoplasmosis

Abbas Mirshafiey1,Nahid Darabi2 1 Department of Immunology,School of Public Health,Tehran University of Medical Sciences,Tehran-14155,Box:6446,Iran 2 Department of Medical Mycology,University of Tarbiat Modarres,Tehran,Iran Correspondence to Professor Abbas Mirshafiey,Departmant of Immunology,School of Public Health,Tehran University of Medical Sciences,Tehran-14155,Box:6446,Iran E-mail：mirshafiey@tums.ac.ir

[Abstract]Elements that are key in the innate response include dendritic cells,neutrophils,and macrophages.Several cytokines of the innate system are crucial for the generation of a protective immune response.interleukin-12 is essential in the generation of IFN-γ and consequently the Th1 response.TNF-α and GM-CSF are also key cytokines in the generation of a protective immune response.IFN-γ,TNF-α,and GM-CSF regulate the immune system in part by inducing the production of nitric oxide,a necessary molecule in the elimination of the fungus during primary infection.In addition,GM-CSF also appears to regulate the production of IFN-γ and TNF-α.IL-4 and IL-10 both appear to inhibit full expression of a robust Th1 response in the innate immune system.In the adaptive immune response CD4+ T cells are the dominant mediators of resistance in primary infection although CD8+ cells do contribute to the expression of an optimal protective response,activation of an effective T cell-mediated immune response most likely requires upregulation in IFN-γ,TNF-α,and GM-CSF but not IL-4,IL-10,or CD40L.In this review,our aims is to clarify the mechanism of immune response in histoplasmosis.

Full text : HTML PDF

[Document Indexing]

Abbas Mirshafiey1,Nahid Darabi2 .Immune response in histoplasmosis .Journal of Chinese Clinical Medicine,2010,5(2):100-109.

[Reference Document]

1. A,Motta.,R,Galo.,A,Loureno.,C,Komesu.,F,Velasco.,C,Garcia,Y.J.Mycopathologia,2006,161,161.

2. G.S,Deepe.,R,Gibbons,Y.J.Antimicrob.Agents Chemother,2000,44,3328.

3. T.L.Wang1.,J.S.Cheah1 and K.Holmberg,Y.J.clinical and epidemiological implications.Journal of Immunology,2001,166.

4. M.D,RENE KUROWSKI.,M.D,MICHAEL OSTAPCHUK,Y.J.reviewed of theAmerican Academy of family physicians,2002,400-405.

5. PV,Bhagwat.,K,Hanumanthayya.,RS,Tophakhane.,RM,Rathod.Y.J.IJDVL,2009,173-176.

6. C,Tichindelean.,JW,East.,JC,Sarria,Y.J.Med Sci,2009,238-240.

7. JW,Gurney.,DJ,Conces,Y.J.Radiology,1996,199,297.

8. A,Bonifaz.,P,Chang.,K,Moreno.,V,Fernández.,G,Montes de Oca.,J,Araiza.,RM,Ponce,Y.J.Clin Exp Dermatol,2009,481-486.

9. DJ Jr,Conces.Y.J.Semin Roentgenol,1996,31,14.

10. J,Wheat,Y.J.Medicine,1997,76,339.

11. DHHS (NIOSH) PUBLICATION HISTOPLASMOSISY.Protecting Workers at Risk,1997,97,146.

12. CA,Kauffman,YJ.Clin Chest Med,.2009,217-225.

13. ZT,Hammoud.,AS,Rose.,CA,Hage.,KS,Knox.,K,Rieger.,KA,Kesler,YJ.Ann Thorac Surg,2009,399-403.

14. RW,Bradsher,Y.J.Clin Infect Dis,1996,22,S102.

15. MM,Durkin.,PA,Connolly.,LJ,Wheat.,Y.J.Clin Microbiol,1997,35,2252.

16. S,Maxson.,RF,Jacobs,Y.J.Semin Respir Infect,1996,11,196.

17. L,Pine,Y.J.contrib.Microbiol.Immunol,1997,3,138.

18. Siew Fah Yeo and Brain Wong,Y.J.Clinical Microbiology Reviews,2002,15,465.

19. E,Reiss.,I.B,Knowless,S.L.Bragg and Koafman,Y.J.Infect immune,1986,53,540.

20. RM,Zancope-Olivera.,S.L,Bragg.,E.Riess and J.M.Peralta,Y.J.Clin.Diagn.Lab.Immunol,1994,1,563.

21. R,Chandrashekar.,K.C.Curtis.,B.W,Rawot.,G.S,Kobayashi,andG.J,Weil,Y.J.Clin.Microbiol,1997,35,1071.

22. G.S,Deepe.,G.G,Durose,Y.J.Infect.Immun,1995,63,3151.

23. AJ,Hamilton,Y.J.Med.Mycol,1998,36,351.

24. Y,Mikm,Y.J.NIPPON ISHIKIN GAKKAI ZASSHI,2008,49,151.

25. US Patent Issued,Y.J.Nature Reviews Microbiology,2004,5,167.

26. A,Chad.,Rappleye.,Linda Groppe Eissenberg,and E,Goldman,Y.J.Infect.Immun,1999,37,2387.

27. KM,Frank.,DK,Hogarth.,JL,Miller.,S,Mandal.,PJ,Mease.,RJ,Samulski,GA,Weisgerber.,J,Hart,J,Med,161-169.

28. A,Rappleye,L,Eissenberg,and William E.Goldman,Y.J.PNAS,2007,104,1366.

29. CA,Sorgi.,A,Secatto.,C,Fontanari.,WM,Turato.C,Belangér.AI,de Medeiros.,S Kashima.,S,Marleau.,PT,Bozza.,LH,Faccioli,Y.J.Immunol,2009,4025-4035.

30. RN,Aravalli.,JP,Woods,JR,Lokensgard,Y.J.Neuroinflammation,2008,7,5.

31. P,Gorocica.,ML,Taylor,N,Alvarado-Vásquez.,A,Pérez-Torres.,R,Lascurain.,E,Zenteno,Y.J.Mem Inst Oswaldo Cruz,2009,492-496.

32. LJ,Wheat.,RL,Baker.,MF,Curfman.,ME,Eads.,KS,Israel.,SA,Norris.,DH,Webb.,ML,Zeckel,Y.J.Med,1990,69,361.

33. LJ,Wheat.,P,Connolly-Stringfield.,RB,Kohler.,PT,Frame.,MR,Gupta,Y.J.Med,1989,87,396.

34. AC,Pasqualotto.,FM,Oliveira.,LC,Severo,Y.J.Mycopathologia,2009,315-23.

26. LJ,Wheat,Y.J.Clin.Infectious Dis,1992,14,91.

35. H,Joseph Wheat.,P,Connolly.,K,Kleiman.,K,Nelson.,R,Bradsher and A,Restrepo,Y.J.CID 1997,,24

36. L,Egan.,PA,Connolly.,D,Fuller.,TE,Davis.,J3rd,Witt.,KS,Knox.,CA,Hage.,LJ,Wheat,Y. J.Clin Vaccine Immunol,2008,15,726.

37. SE,Zimmerman.,P,Connolly Stringfield.,LJ,Wheat.,MLV,French.,Kohler,Y. J.Infect Dis,1989,160,678.

38. CA,Kauffman,Y.J.Curr Opin Infect Dis,2008,4,421.

39. CA,Kauffman Y.J.Curr Opin Infect,2008,4,421

40. TG,Mitchell.,WK,Joklik,P,Willett.,DB,Amos.,GM,Wifert,eds.Y.Zinsser microbiology.20th ed.Norwalk,CT:Appleton and Lange,1992,1091-1112.

41. SF,Davies,Y.J.Semin.Respir.Infections,1990,5,93.

42. PC,Johnson.,GA,Sarosi,Y.J.Med,1987,9,145.

43. S,George.,Jr,Deepe.,S,Reta.,A,Smulian,Y.J.Clinical and Vaccine Immunology,2008,15,681.

44. ME,Gutierrez.,A,Canton.,P,Connoly.,R,Zarnowski.,LJ,Wheat,Y.J.Clinical and Vaccine Immunology,2008,15,4

45. MVN O’Sullivan.,M,Whitby.,C,Chahoud.,SM,Miller,Y.J.Australian Dental,2004,49,94.

46. E,Brummer.,N,Kurita.,S,Yosihida.,K,Nishimura.,andM,Miyaji,Y.J.Infect.Dis,1991,164,158.

47. N,Kurita.,E,Brummer.,S,Yoshida.,K,Nishimura.,andM,Miyaji,Y.J.Med.Vet. Mycol,1991a,29,133.

48. SL,Newman.,L,Gootee.,andJE,Gabay,Y.J.Clin.Invest,1993,92,624.

41. J.A,Maatta.,U.R,Sjoholm.,P.T,Nygardas.,A.ASalmi.,and A.E,Hinkkanen,Y. J.Neuroimmunol,1998,90,162.

49. L,Romani.,A,Mencacci.,E,Cenci.,R,Spaccapelo.,G,Del Sero.,I,Nicoletti.,G,Trinchieri.,F,Bistoni.,and P,Puccetti,Y.J.Immunol,1997,158,5349.

50. JS,Lin.,CW,Yang.,DW,Wang.,BA,Wu-Hsieh BA,Y.J.Immunol,2005,174,6282.

51. B,Huffnagle.,S,Deepe,Y.This review comes from a themed issue on Host-microbe interactions:fungi Edited by Bruce Klein,2003,6,344.

52. L.A,Gildea.,R.E,Morris.,S.L,Newman,Y J.Immunol,.2001,166,1049.

53. RM,Syme.,JC,Spurrell.,EK,Amankwah.,FH,Green.,CH,Mody,Y.J.Infect Immun,2002,70,5972.

54. LA,Gildea.,RE,Morris.,SL,Newman,Y.J Immunol,2001,166,1049.

55. TR,Traynor.,AC,Herring.,ME,Dorf.,WA,Kuziel.,GB,Toews.,GB,Huffnagle,Y.J.Immunol,2002,168,4659.

56. TR,Traynor.,WA,Kuziel.,GB,Toews.,GB,Huffnagle,Y.J.Immunol,2000, 164,2021.

57. SK,Bauman.,GB,Huffnagle.,JW,Murphy,Y.J.Infect Immun,2003,71,68.

58. S,Bozza.,R,Gaziano.,A,Spreca.,A,Bacci.,C,Montagnoli.,P,di Francesco.,L,Romani,Y.J.Immunol,2002,168,1362.

59. R,Forster.,A,Schubel.,D,Breitfeld.,E,Kremmer.,I,Renner-Muller.,E,Wolf.,M,Lipp,Y. J.Cell 1999,99,23.

60. H,Saeki.,AM,Moore.,MJ,Brown.,ST,Hwang,Y.J.Immunol,1999,162,2472.

61. P,McGuirk.,KH,Mills,Y.J.Trends Immunol,2002,23,450.

62. S,Hori.,TL,Carvalho.,J,Demengeot,Y.J.Immunol,2002,32,1282.

63. C,Montagnoli.,A,Bacci.,S,Bozza.,R,Gaziano.,P,Mosci.,AH,Sharpe.,L,Romani,Y.J.Immunol,2002,169,6298.

64. A,Bacci.,C,Montagnoli.,K,Perruccio.,S,Bozza.,R,Gaziano.,L,Pitzurra.,A,Velardi.,CF,d’Ostiani.,JE,Cutler.,L,Romani,Y.J.Immunol,2002,168,2904.

65. S,Bozza.,R,Gaziano.,GB,Lipford.,C,Montagnoli.,A,Bacci.,P,Di Francesco.,VP,Kurup.,H,agner.,L,Romani,Y.J.Microbes Infect,2002,4,1281.

66. W.E,Bullock.,S.D,Wright,Y.J.Exp.Med,1987,165,195.

67. S.L,Newman et al.Y.J.Clin.Invest,1990,85,223.

68. L,Simon.,Newman,Y.J.Trends inMicrobiology,1999,7,2 67.

69. C.L.Kimberlin et al,Y.J.Infect.Immun,1981,34,.6.

70. G,Eissenberg.,W.E.Goldman,Y.J.Infect.Immun,1987,55,29.

71. J.E,Wolf et al,Y.J.Immunol,1987,138,582.

72. J.E.Wolf et al,Y.J.Infect.Immun,1989,57,513.

73. D.H,Howard,Y.J.Bacteriol,1985,89,518.

74. S.L,Newman.,L,Gootee.,J.E.Gabay,Y.J.Clin.Invest,1993,92,24.

75. P,Eissenberg.,P.H,Schlesinger.,W.E.Goldman,Y.J.Leukocyte Biol.,1988,43,483.

76. M.L,Taylor et al,Y.J Clin.Exp.Immunol,1989,75,466.

77. S.L,Newman et al,Y.J.Immunol,1997,158,1779.

78. S.L,Newman et al,Y. J.Immunol,1992,149,580.

79. L.G,Eissenberg.,W.E,Goldman.,P.H.Schlesinger,Y.J.Exp.Med,1993,177,1605.

80. S.L,Newman et al,Y.J.Immunol,1992,149,574.

81. A.N,Lestas,Y.J.Haematol,1986,32,341.

82. E,Lane.,B.A,Wu-Hsieh.,D.H.Howard,Y.J.Infect.Immun,1991,59,2274.

83. S.L,Newman Y et al.J.Clin.Invest,1994,93,1422.

84. LY,Chao.,MA,Maletta.,J,Rine,Y.J.Biochemistry,2008,47,7274.

85. R,Zanowski.,A,Dobrzyn.,JM,Ntambi.,GP,Woods,Y.J.Curr.Microbiol,2008,2,153.

86. GS,Deep.,RS,Gibbons.,AG,Smulian,Y.J.Leukoc Biol,2008,24.

87. G.L,Lukacs,O.D,Rotstein.,S.Grinstein,Y.J.Biol.Chem,1990,265,21009.

88. G.L,Lukacs.,O.D.Rotstein.,S.Grinstein,Y.J.Biol.Chem,1991,266,24540.

89. P,Zhou.,G,Miller.,R.A,Seder,Y.J.Immunol,1998,60,1359.

90. J,Fleischmann.,B,Wu-Hsieh.,D.H,Howard,Y.J.Infect.Dis,1990,161,143.

91. S.L,Newman.,L.Gootee,Y.J.Infect.Immun,1992,11,4593.

92. R,Allendoerfer.,GD,Brunner.,GS,Deepe,Y.J.Immunol,1999,162,7389.

93. LJ,Wheat.,PA,Connolly-Stringfield.,RL,Baker.,MF,Curfman.,ME,Eads.,KS,Israel.,SA,Norris.,DH,Webb.,ML,Zeckel,Y.J.Medicine (Baltimore),1990,69,361.

94. P,Zhou.,L,Brenda.,C,Charles,Y.J.Immunology,2001,166,1968.

95. R,Allendoerfer.,G.D,Brunner.,Jr G.S.Deepe,Y.J.Immunol,1999,162,7389.

96. A,Gomez.,M,W.E.Bullock.,C.L,Taylor.,Jr G.S.Deepe,Y.J.Infect.Immun,1988,56,1685.

97. P,Zhou.,G,Miller.,R.A,Seder,Y.J.Immunol,1998,160,1359.

98. RN,Aravalli.,JP,Woods.,Lokengard,YJ.Neuroinflamation,.2008,5,30.

99. R,Allendoerfer.,GS,Deep,Y.J.InfectImmun,1997,7,2564.

100. GS,Deep.,RS,Gibbbons,Y.J.Immunol,2003,171,5353.

101. GS,Deep.,RS,Gibbons,Y.J.Immunol,2008,180,1088.

102. TE,Lane.,BA,Wu-Hsieh.,DH,Howard,Y.J.Infect.Immun,1991,59,2274.

103. JD,Brunker.,JP,Hoover,Y.J.CanVet,2007,3,292.

104. JD,Nosanchuk.,JN,Steenbergen.,L,Shi.,GS,Deepe.,A,Casadevall,Y.J.Clin.Invest,2003,112,1164 .

105. L,Shi.,PC,Albuquerque.,E,Lazar-Molnar.,X,Wang.,L,Santambrogio.,A,Gácser.,JD,Nosanchuk,Y.J.Eukaryot Cell,2008,7,1109.

106. JA,Winkelstein.,MC,Marino.,H,Ochs.,R,Fuleihan.,PR,Scholl.,R,Geha.,ER,Stiehm.,Y.J.Medicine (Baltimore),2003,82,373.

107. P,Zhou.,RA,Seder,Y.J.Exp.Med,1998,187,1315.

108. LJ,Wheat.,M,Durkin.,C,Schnizlein-Bick.,E,Bassey.,S,Kohler.,P,Connolly.,J,Goldberg .,T,Garringer.,E,Brizendine.,EK,Thomas,Y.J.Med.Mycol,2002,40,501.

109. GS,Deepe.,R,Gibbons,Y.J.Infect.Immun,2001,69,3128.

110. FJ,Gomez.,R,Allendoerfer.,GS,Deepe,Y.J.Infect Immun,1995,7,2587.

111. GS,Deepe.,RS,Gibbons,Y.J.Infect.Dis,2002b,186,815.