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Misconduct and beyond in medical research：the retinoblastoma paradigm
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Domenico Mastrangelo1，Theodora Hadjistilianou2，Sonia De Francesco2，Cosimo Loré1 1 Department of Biomedical Sciences，Policlinico Le Scotte，Viale Bracci n.2，University of Siena，Siena 531000，Italy
2 Department of Ophthalmology，Policlinico Le Scotte，Viale Bracci n.2，University of Siena，Siena 531000，Italy
Correspondence to Domenico Mastrangelo，MD，Department of Biomedical Sciences，University of Siena，Siena 531000,Italy；E-mail：mastrangelo@unisi.it
[Abstract]INTRODUCTION Retinoblastoma (Rb) represents the prototype of cancer linked to the sequential loss or inactivation of both alleles of a so called “tumour suppressor gene”，the Rb1 gene. The pathogenetic mechanism behind this tumour was first hypothesized by Knudson in 1971 and further confirmed by geneticists and molecular biologists who identified the gene (Rb1) whose loss or i...
[Document Indexing]
Domenico Mastrangelo1，Theodora Hadjistilianou2，Sonia De Francesco2，Cosimo Loré1.Misconduct and beyond in medical research：the retinoblastoma paradigm.Journal of Chinese Clinical Medicine,2009,4(11):601-603.
[Reference Document]
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