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Prevalence of Helicobacter pylori in gastric mucosa and dental plaque in Sari,northern Iran
- Mohtaram Nasrolahei1，Mehdi Sharif2，Mohammad Ahanjan1，Ahmad Daryani2 Department of Microbiology and Immunology1,Department of Parasitology and Mycology2,Sari Medical School,Mazandaran Unuversity of Medical Sciences,Sari,Iran Corresponddence to Mohtaram Nasrolahei,Ph.D,Department of Microbiology and Immunology,Sari Medical School,Mazandaran Unuversity of Medical Sciences,Sari,Iran E-mail: mnasrolahei@yahoo.ca
[Abstract]Objective The role of Helicobacter pylori in gastrointestinal disease such as peptic ulcer and gastric cancer is well known. Dental plaque has been considered as a potential reservoir of gastric infection and reinfection. The aim of this study was to determine the prevalence of Helicobacter pylori in dental plaque and gastric mucosa in Sari township population and to investigate its association with oral hygiene.Methods Two hundred and sixty individuals of rural and urban population of Sari township who had a positive H. pylori serology or positive rapid urease test or histologic evidence for the presence of H. pylori in their gastric mucosa, were examined. These patients were divided into 3 groups determined by Oral Hygiene Index （OHI）, scores of good, fair, and poor. Dental plaque was analyzed by a PCR for a specific internal urease A gene.Data were analyzed by using SPSS 11.5 and descriptive and analytical tests.Results H. pylori was detected in stomach of 57.8% of tested individuals. There was a high prevalence of H. pylori （46 % ） in the dental plaque of individuals with gastric H. pylori infection. H. pylori positivity in dental plaque was correlated with OHI scores; the positivity was 10.8% , 25 % and 64.1% in individuals with good, fair, and poor OHI scores respectively. Conclusion The demonstration of the organism in the mouths of a substantial proportion of gastric patients has major implications for the spread of H. pylori. However, if the oral cavity is a reservoir for gastric infection, this should be sufficient to warrant a preventive approach that encompasses consideration of the oral reservoir.
[Document Indexing]
Mohtaram Nasrolahei1，Mehdi Sharif2，Mohammad Ahanjan1，Ahmad Daryani2.Prevalence of Helicobacter pylori in gastric mucosa and dental plaque in Sari,northern Iran .Journal of Chinese Clinical Medicine,2008,3(7):383-388.
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